Researchers from Institute of medical pharmaceutical and health science, Kanazawa University report in eBioMedicine that elucidate the cross-species genomic interactions between Epstein Barr virus (EBV) and host cells. This study performed by Dr. Harue Mizokami and Professor Tomokazu Yoshizaki from Kanazawa University, Professor Atsushi Kaneda from Chiba University, and Associate Professor Melissa Jane Fullwood from Nanyang Technological University (Singapore).?
These findings provide important insight into the mechanism of virus-mediated tumorigenesis and are expected to be useful in establishing new treatments for nasopharyngeal cancer in the future.
The present study has been published as an online version in the academic journal『?eBioMedicine』on March 14, 2024.
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Fig：Researchers elucidate the cross-species genomic interactions between Epstein-Barr virus (EBV) and host cells.?
EBV interacts at specific locations within the B compartment of the host chromatin structure and hijacks gene enhancers. The activation of enhancers activates the expression of PLA2G4A, PTGS2, and CITED2, which leads to uncontrolled cell proliferation.
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Click here to see the press release【Japanese only】
Journal：eBioMedicine
Researcher's Information：Tomokazu Yoshizaki?
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